MOTS-c — Mitochondria-Derived Peptide for Metabolic Programming Research
MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a mitochondria-derived peptide (MDP) consisting of 16 amino acids, encoded within the 12S rRNA gene of mitochondrial DNA. The discovery of MOTS-c represented a paradigm shift in the understanding of mitochondrial biology, establishing that the mitochondrial genome encodes bioactive peptide signals that function beyond the organelle itself. In research settings, MOTS-c has been extensively studied for its effects on cellular metabolic programming, particularly its influence on the folate-methionine cycle, de novo purine biosynthesis, and AMPK activation pathways.
In vitro studies using skeletal muscle cell lines, adipocytes, and hepatocytes have demonstrated that MOTS-c exposure results in measurable alterations in metabolic flux, gene expression profiles, and cellular energy status as assessed by ATP:ADP ratio measurements and oxygen consumption rate analyses. Researchers have also examined the role of MOTS-c in exercise biology, aging research, and metabolic stress response, making it one of the most versatile mitochondrial peptide research tools currently available. The unique mitochondrial origin of this peptide provides investigators with a novel molecular probe for studying retrograde mitochondrial-nuclear communication, a frontier area in modern cell biology.
Coffee & Pepper Peptides supplies MOTS-c as a high-purity, lyophilized research peptide with complete analytical documentation including HPLC purity data and mass spectrometric confirmation. This product is intended solely for laboratory research purposes and is not approved for human or animal use.
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The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.
All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.
Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.
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