MT-2

MT-2 — Non-Selective Melanocortin Receptor Agonist for Receptor Pharmacology

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (alpha-MSH) that functions as a non-selective agonist at melanocortin receptor subtypes MC1R through MC5R. This lactam-bridged peptide, with the sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, was originally developed as a research tool for investigating melanocortin receptor pharmacology and the diverse physiological processes regulated by the melanocortin system across various tissue types and cell lineages.

In laboratory studies, MT-2 has been employed to study melanogenesis in melanocyte cell cultures, examining the intracellular signaling cascade from MC1R activation through adenylyl cyclase stimulation, cAMP elevation, PKA activation, CREB phosphorylation, and ultimately MITF-dependent transcription of melanogenic enzymes including tyrosinase, TRP-1, and TRP-2. Beyond melanocyte biology, MT-2 serves as a valuable tool for researchers investigating the broader melanocortin system, including its roles in energy homeostasis signaling, cardiovascular regulation pathways, and neuroendocrine function in hypothalamic cell models. The non-selective receptor profile makes MT-2 particularly useful for comparative subtype contribution studies.

Each vial contains research-grade MT-2 verified for purity and identity by HPLC and mass spectrometry. Coffee & Pepper Peptides provides this compound strictly as a research chemical for scientific investigation. It is not intended for human use, cosmetic application, or any non-research purpose.

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The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.

All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.

Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.