SEMAX

Semax — ACTH Fragment Analog for Neuroprotection Research

Semax is a synthetic heptapeptide analog of the adrenocorticotropic hormone (ACTH) fragment 4-10, bearing the sequence Met-Glu-His-Phe-Pro-Gly-Pro, with the C-terminal Pro-Gly-Pro extension serving as a metabolic stabilizer. This structural modification confers enhanced resistance to aminopeptidase and carboxypeptidase degradation, extending the effective experimental window of the peptide in cell culture and tissue preparation studies. Semax has been a cornerstone reagent in neuroscience research for investigating neurotrophic and neuroprotective signaling mechanisms across multiple model systems.

Published literature documents the effects of Semax on BDNF and NGF expression in hippocampal and cortical neuronal cultures. Studies have also examined the influence of Semax on dopaminergic and serotonergic neurotransmission pathways, its modulation of immediate early gene expression (including c-Fos and c-Jun), and its effects on long-term potentiation (LTP) in electrophysiological assay systems. The peptide has further been studied in models of oxidative stress, excitotoxicity, and neuroinflammation, making it a versatile research tool for investigators exploring neuroprotective signaling cascades and their molecular determinants in neuronal cell populations.

Each vial is supplied as a lyophilized powder with documented purity and identity. Coffee & Pepper Peptides provides Semax exclusively as a research reagent for qualified scientific investigators. It is not approved for human or veterinary use.

FDA DISCLAIMER

The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.

All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.

Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.