THYMOSIN ALPHA 1

Thymosin Alpha 1 — Immunomodulatory Peptide for Immune Cell Biology Research

Thymosin Alpha 1 (T-alpha-1) is a naturally occurring 28-amino acid peptide originally isolated from thymic tissue and characterized as a key regulator of immune cell maturation and function. In laboratory research, Thymosin Alpha 1 has been extensively studied for its immunomodulatory properties, with published investigations documenting its effects on dendritic cell maturation, T-lymphocyte differentiation, natural killer cell activation, and toll-like receptor signaling pathways across diverse immune cell populations and experimental model systems.

The peptide acts primarily through TLR9 and TLR2 agonism, initiating MyD88-dependent signaling cascades that culminate in the activation of NF-kB and IRF-7 transcription factors and the subsequent induction of type I interferon and pro-inflammatory cytokine expression. In vitro studies using peripheral blood mononuclear cell (PBMC) preparations and purified immune cell subsets have demonstrated that Thymosin Alpha 1 promotes phenotypic maturation of dendritic cells, enhances antigen presentation capacity, and modulates the Th1/Th2 cytokine balance in a concentration-dependent manner. Researchers studying adaptive immunity, vaccine adjuvant biology, and immunosenescence mechanisms have found Thymosin Alpha 1 to be a valuable experimental reagent.

Coffee & Pepper Peptides supplies Thymosin Alpha 1 as a high-purity lyophilized peptide for research use only. It is not intended for human or veterinary administration or any clinical application.

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The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.

All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.

Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.