TB-500 Kit (10 Vials)

TB-500 — Thymosin Beta-4 Fragment for Cytoskeletal Research

TB-500 is a synthetic peptide fragment corresponding to the active region of thymosin beta-4, a 43-amino acid protein that is one of the most abundant intracellular peptides in mammalian cells. Specifically, TB-500 encompasses the actin-binding domain of thymosin beta-4, centered around the sequence LKKTETQ, which has been demonstrated to play a pivotal role in actin polymerization dynamics and cytoskeletal organization in cell biology research. The interaction of TB-500 with G-actin monomers provides researchers with a precise molecular tool for manipulating the actin polymerization equilibrium.

In laboratory settings, TB-500 has been extensively studied for its effects on cellular migration, with wound healing scratch assays and transwell migration experiments consistently demonstrating enhanced motility of endothelial cells, keratinocytes, and corneal epithelial cells upon exposure to this peptide. Researchers have also investigated the influence of TB-500 on endothelial tube formation assays and matrigel angiogenesis models, reporting dose-dependent increases in tubulogenesis parameters. Additional areas of investigation include effects on inflammatory mediator expression, metalloproteinase activity, and the balance between pro- and anti-inflammatory cytokine profiles in immune cell culture systems.

Coffee & Pepper Peptides provides TB-500 as a lyophilized research peptide with documented purity and identity. This product is intended exclusively for scientific research and is not intended for human or animal use.

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The information provided on this website has not been evaluated by the U.S. Food and Drug Administration (FDA). None of the statements herein, nor any of the products offered, are intended to diagnose, treat, cure, or prevent any medical condition.

All products are supplied strictly as laboratory research reagents and are not for human consumption. We do not provide products to patients and do not make any claims regarding medical use.

Coffee & Pepper Peptides operates solely as a chemical supplier. It is not a compounding pharmacy and does not operate as a compounding facility under Section 503A of the Federal Food, Drug, and Cosmetic Act.